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KMID : 0381920010310030275
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Korean Journal of Microscopy
2001 Volume.31 No. 3 p.275 ~ p.285
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Increase of Alveolar Macrophages Contributes to the Enhanced Xanthine Oxidase Activity in the Bronchoalveolar Lavage Fluid of Rats Given IL-1 Intratracheally
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Cho Hyun-Gug
Yoon Chong-Guk
Choi Jeung-Mog
Park Won-Hark
Lee Young-Man
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Abstract
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The pulmonary alveolar macrophage is thought to play an important role in the mediation of acute inflammatory lung injury by secretory products including degraded enzymes, cytokines, and reactive oxygen metabolites . This study was conceived to understand the role of alveolar macrophage in oxidative stress induced acute lung injury. To examine the alveolar macrophages and xanthine oxidase (XO) activity in bronchoalveolar lavage fluid (BALF), time-dependent changes of numbers of alveolar macrophages, monocytes and neutrophils in alveolar cavity were counted in association with ultrastructural and cytochemical observations of lung tissue and alveolar cells. The number of monocytes was increased (p<0.001) at 1h after IL-1 treatment compared with that of sham. At 2h after instillation of IL-1, the number of alveolar macrophages was the highest, XO activity in BALF was elevated at 2h after IL-1 instillation and the activity was markedly elevated(p<0.05) at 3h after IL-1 treatment. On the basis of these experimental results, it is suggested that, during early phase of acute lung injury induced by IL-1, alveolar macrophage-derived XO contributes to lung injury earlier than the neutrophilic respiratory burst.
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KEYWORD
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Acute lung injury, Alveolar macrophage, Xanthine oxidase
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